Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967099 | 0.89 | SMN1; SMN2 (0.57) | AKT1MAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL10327053 | 0.79 | MAPT (0.55) | MAPTPOLBSMN1; SMN2TP53LMNA | |
| SCHEMBL10327149 | 0.78 | LMNA (0.53) | MAPTPOLBSMN1; SMN2TP53LMNA | |
| SCHEMBL3459645 | 0.75 | AKT1 (0.60) | AKT1MAPTLMNAALDH1A1GAA | |
| SCHEMBL12947374 | 0.75 | MAPT (0.52) | MAPTPOLBSMN1; SMN2TP53LMNA | |
| SCHEMBL963620 | 0.74 | LMNA (0.52) | MAPTPOLBSMN1; SMN2TP53LMNA | |
| SCHEMBL968558 | 0.74 | LMNA (0.56) | MAPTPOLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL964265 | 0.73 | KMT2A (0.78) | MAPTPOLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL19420176 | 0.72 | MAPT (0.70) | MAPTPOLBSMN1; SMN2TP53LMNA | |
| SCHEMBL966884 | 0.72 | MAPT (0.54) | MAPTPOLBSMN1; SMN2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |