Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | ALB | P02768 | 1/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918 | 0.80 | BRD4 (0.57) | BRD4BRD2BRD3CREBBPBCHE | |
| SCHEMBL16201640 | 0.80 | CSNK2B (0.47) | CREBBPBCHEACHEPOLBHTT | |
| SCHEMBL7291788 | 0.78 | RIPK3 (0.42) | BRD4BRD2BRD3CREBBPBCHE | |
| SCHEMBL15723838 | 0.78 | CSNK2B (0.58) | CREBBPPOLBHTTPRKD3PRKCG | |
| SCHEMBL13345818 | 0.77 | BRD4 (0.51) | BRD4BRD2BRD3CREBBPBCHE | |
| SCHEMBL1391 | 0.77 | BRD4 (0.64) | BRD4BRD2BRD3CREBBPBCHE | |
| SCHEMBL16201649 | 0.75 | CSNK2A2 (0.40) | POLBHTTPRKD3PRKCGPRKCB | |
| SCHEMBL854 | 0.73 | BCHE (0.64) | BCHEACHEALB | |
| SCHEMBL588 | 0.71 | BCHE (0.69) | BRD4BRD2BRD3CREBBPBCHE | |
| SCHEMBL7376810 | 0.71 | BRD4 (0.40) | BRD4BRD2BRD3CREBBPBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| EP-0306323-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1994-09-21 | — | — | EP | disclosed |
| EP-0306323-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-03-08 | — | — | EP | disclosed |