Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032433 | 0.86 | MAPT (0.51) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1035534 | 0.84 | MAPT (0.73) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1034966 | 0.78 | LMNA (0.57) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1030953 | 0.78 | NPC1 (0.55) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1033367 | 0.77 | LMNA (0.56) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1035662 | 0.76 | LMNA (0.57) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1034601 | 0.76 | MAPT (0.50) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1035487 | 0.76 | MAPT (0.54) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1034956 | 0.74 | TP53 (0.56) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL1036696 | 0.74 | MAPT (0.58) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086537-B1 | IMIDAZO[2,1-B]THIAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2011-01-26 | — | — | EP | claimed |