Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 10/20 | 0.58 |
| ▸ | DRD3 | P35462 | 10/20 | 0.58 |
| ▸ | DRD4 | P21917 | 9/20 | 0.58 |
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | HTR7 | P34969 | 5/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.56 |
| ▸ | DRD1 | P21728 | 3/20 | 0.56 |
| ▸ | HRH1 | P35367 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | HTR1E | P28566 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10332824 | 0.97 | DRD2 (0.63) | POLBDRD2DRD3DRD4HTR1A | |
| SCHEMBL10332887 | 0.85 | DRD2 (0.54) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL1136779 | 0.85 | KDM4E (0.55) | DRD2DRD3DRD4HRH1 | |
| SCHEMBL10332832 | 0.83 | HTR2A (0.65) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL10333161 | 0.82 | DRD2 (0.56) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL10332839 | 0.78 | POLB (0.59) | POLBDRD2DRD3DRD4HTR1A | |
| SCHEMBL7329469 | 0.78 | DRD2 (0.64) | POLBDRD2DRD3DRD4HTR1A | |
| SCHEMBL4519313 | 0.77 | KCNH2 (0.85) | POLBDRD2DRD3DRD4HTR1A | |
| SCHEMBL26107525 | 0.77 | KCNH2 (0.85) | POLBDRD2DRD3DRD4HTR1A | |
| SCHEMBL26108725 | 0.77 | KCNH2 (0.85) | POLBDRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935424-A | HYPOTENSIVE AGENTS; TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1990-06-19 | — | — | US | claimed |
| EP-0345533-A1 | Substituted 2-aminothiazoles as dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1989-12-13 | — | — | EP | claimed |
| WO-1989011476-A1 | SUBSTITUTED 2-AMINOTHIAZOLES AS DOPAMINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-11-30 | — | — | WO | claimed |
| US-4935424-A | HYPOTENSIVE AGENTS; TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0345533-A1 | Substituted 2-aminothiazoles as dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1989-12-13 | — | — | EP | disclosed |
| WO-1989011476-A1 | SUBSTITUTED 2-AMINOTHIAZOLES AS DOPAMINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-11-30 | — | — | WO | disclosed |