Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 3/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333269 | 0.93 | PDE10A (0.44) | PDE10ACCR1CCR5CCR8NPC1 | |
| SCHEMBL10334171 | 0.92 | NPC1 (0.39) | PDE10ANPC1RAB9ARUNX1CBFB | |
| SCHEMBL10333779 | 0.90 | PDE10A (0.48) | PDE10ACCR1CCR5CCR8NPC1 | |
| SCHEMBL10333408 | 0.89 | PDE10A (0.40) | PDE10ACCR1CCR5CCR8NPC1 | |
| SCHEMBL10333765 | 0.89 | PDE10A (0.40) | PDE10ACCR1CCR5CCR8NPC1 | |
| SCHEMBL10332972 | 0.87 | NPC1 (0.39) | PDE10ACCR1CCR5CCR8NPC1 | |
| SCHEMBL10333105 | 0.86 | AMY1A (0.39) | PDE10ANPC1RAB9ACBFBMETAP1 | |
| SCHEMBL10333292 | 0.85 | CBFB (0.45) | NPC1RAB9ACBFBMETAP2METAP1 | |
| SCHEMBL10333297 | 0.85 | PDE10A (0.46) | PDE10ANPC1RAB9ACBFBSYK | |
| SCHEMBL10333461 | 0.84 | CCR1 (0.41) | PDE10ACCR1CCR5CCR8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | claimed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | claimed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | claimed |
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | disclosed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |