Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333104 | 0.81 | KMT2A (0.51) | POLBHPGDHDAC1HDAC6KMT2A | |
| SCHEMBL10333189 | 0.81 | POLB (0.40) | POLBHPGDHDAC1HDAC6KMT2A | |
| SCHEMBL11187456 | 0.80 | CYP19A1 (0.41) | POLBHPGDHDAC1HDAC6KMT2A | |
| SCHEMBL10333042 | 0.75 | HMOX1 (0.49) | — | |
| SCHEMBL5925447 | 0.74 | CYP19A1 (0.51) | CYP19A1CYP3A4 | |
| SCHEMBL14476866 | 0.74 | CYP19A1 (0.56) | HDAC1HDAC6CYP19A1 | |
| SCHEMBL4249454 | 0.73 | POLB (0.50) | POLBHPGDHDAC1HDAC6HSP90AA1 | |
| SCHEMBL10333391 | 0.72 | CYP1A2 (0.44) | HDAC1HDAC6KMT2AHSP90AA1CYP3A4 | |
| SCHEMBL27956483 | 0.72 | HSP90AA1 (0.51) | POLBHPGDKMT2AHSP90AA1MEN1 | |
| SCHEMBL9826863 | 0.72 | HSP90AA1 (0.54) | HDAC1HDAC6KMT2AHSP90AA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933357-A | 1,3-diazolyl-2-phenylalkyl-2-propanol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-12 | — | — | US | disclosed |
| EP-0250198-A2 | Bis-azolyl compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-12-23 | — | — | EP | disclosed |