HMOX1

Heme oxygenase 1 · P09601 · HMOX1 on Sugi Atlas →

4,791 patent compounds predicted against HMOX1, 2,832 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL407935)	1.00	4/20
SCHEMBL3694714	1.00	4/20
Hydrochloric Acid (SCHEMBL407854)	0.78	4/20
Hydrochloric Acid (SCHEMBL410065)	0.78	4/20
Hydrochloric Acid (SCHEMBL410852)	0.78	4/20
Hydrochloric Acid (SCHEMBL407946)	0.77	4/20
SCHEMBL442925	0.77	4/20
Hydrochloric Acid (SCHEMBL410009)	0.71	4/20
SCHEMBL443911	0.70	4/20
SCHEMBL5126874	0.52	4/20
SCHEMBL4527352	0.51	4/20
SCHEMBL4083458	0.51	4/20
SCHEMBL4093739	0.50	4/20
SCHEMBL4532938	0.50	4/20
SCHEMBL2678561	0.46	4/20
SCHEMBL1336775	0.44	4/20
SCHEMBL2678543	0.44	4/20
SCHEMBL443910	0.43	4/20
SCHEMBL2677636	0.41	4/20
SCHEMBL1888166	0.39	4/20

Clinical trials — most relevant to HMOX1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy	PHASE4	WITHDRAWN
Effect of Krill Oil Supplementation on Red Blood Cell Physiology Against Changes in Markers of Iron Metabolism.	PHASE4	UNKNOWN
Heme Arginate in Cardiac Surgery Patients	PHASE2	COMPLETED
Carbon Monoxide Therapy for Severe Pulmonary Arterial Hypertension	PHASE1/PHASE2	WITHDRAWN
Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)	PHASE2	UNKNOWN
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial	PHASE1/PHASE2	UNKNOWN
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy	PHASE2	RECRUITING
Hemin in Healthy Subjects	PHASE1	COMPLETED
Feasibility Test of Folic Acid on Acute Kidney Injury	EARLY_PHASE1	NOT_YET_RECRUITING
Folate Treatment to Reduce Death Risk in the Year After Infection-Related Acute Kidney Injury	EARLY_PHASE1	NOT_YET_RECRUITING
Relationship Between Heme Oxygenase 1 Enzyme Level and Coronary SYNTAX Score	nan	COMPLETED
Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN	nan	COMPLETED
FFR Versus iFR in Assessment of Hemodynamic Lesion Significance	nan	UNKNOWN
Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC in Subjects With COVID-19	nan	COMPLETED
Short-Term Broccoli Supplementation and Acute Oxidative Stress Recovery	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Effect Inhaled Nitric Oxide in Adult Liver Transplant	nan	NOT_YET_RECRUITING
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Involvement of Pollutants in Atopic Dermatitis and Psoriasis	nan	UNKNOWN
Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC as an Immune System Enhancer Along With Vaccination Against COVID-19	nan	WITHDRAWN
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy	nan	COMPLETED
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy	nan	RECRUITING
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED
Effects of Hypoxic Breathwork	nan	RECRUITING
Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer	nan	COMPLETED
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection	nan	UNKNOWN
Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a HMOX1 binder may also engage these)

Protein	Name	Similarity
P06762	—	1.000	P06762 →
Q5R7E3	—	0.997	Q5R7E3 →
P14901	—	0.996	P14901 →
P32394	—	0.994	P32394 →
Q5E9F2	—	0.994	Q5E9F2 →
P14791	—	0.987	P14791 →
Q4V7A9	—	0.966	Q4V7A9 →
E9Q4Z2	—	0.966	E9Q4Z2 →
Q2PG53	—	0.965	Q2PG53 →
Q6ZT62	—	0.965	Q6ZT62 →
Q5R6S0	—	0.963	Q5R6S0 →
ABHD16A	Phosphatidylserine lipase ABHD16A	0.962	landscape →
Q6MG55	—	0.961	Q6MG55 →
Q4FZX0	—	0.961	Q4FZX0 →
Q9Z1Q2	—	0.961	Q9Z1Q2 →
Q9BSK4	—	0.961	Q9BSK4 →
Q5E9N5	—	0.961	Q5E9N5 →
Q29RM5	—	0.961	Q29RM5 →
ACACB	Acetyl-CoA carboxylase 2	0.960	landscape →
Q9Z2G1	—	0.960	Q9Z2G1 →
Q9BXI3	—	0.959	Q9BXI3 →
RIOX2	Ribosomal oxygenase 2	0.959	landscape →
Q1JPD2	—	0.958	Q1JPD2 →
Q3UHG7	—	0.958	Q3UHG7 →
A4D1U4	—	0.958	A4D1U4 →
Q0PGW2	—	0.958	Q0PGW2 →
Q0VCQ1	—	0.957	Q0VCQ1 →
A3KFX0	—	0.957	A3KFX0 →
Q641K1	—	0.957	Q641K1 →
Q8NFZ0	—	0.957	Q8NFZ0 →