Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | NOS3 | P29474 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 1/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.52 |
| ▸ | RELA | Q04206 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333867 | 0.81 | MEN1 (0.48) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL10333625 | 0.79 | NPC1 (0.61) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| Water SCHEMBL6484483 | 0.77 | SMN1; SMN2 (0.77) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| Water SCHEMBL6484487 | 0.77 | SMN1; SMN2 (0.77) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL29706525 | 0.77 | RAB9A (0.74) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL9833507 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL2985096 | 0.77 | RAB9A (0.74) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL10333944 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL11016036 | 0.76 | SMN1; SMN2 (0.60) | SMN1; SMN2NOS3NOS1NOS2RAB9A | |
| SCHEMBL18470699 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2NOS3NOS1NOS2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| US-4851419-A | Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity | FISONS PLC (GB) | 1989-07-25 | — | — | US | disclosed |