Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyphylline SCHEMBL5198235 | 0.87 | LMNA (0.75) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| SCHEMBL17682217 | 0.84 | LMNA (0.54) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| SCHEMBL11406664 | 0.83 | MAPK1 (0.60) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| SCHEMBL16675435 | 0.83 | MAPK1 (0.64) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| SCHEMBL17682216 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| SCHEMBL16058831 | 0.80 | MAPK1 (0.67) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| SCHEMBL27324978 | 0.79 | LMNA (0.48) | SMN1; SMN2LMNAPOLBCYP3A4ADORA2A | |
| SCHEMBL381684 | 0.79 | PDE4A (0.71) | SMN1; SMN2LMNAPOLBMAPK1CYP3A4 | |
| Dyphylline SCHEMBL123781 | 0.78 | LMNA (1.00) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 | |
| Dyphylline SCHEMBL1816552 | 0.78 | LMNA (1.00) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315401-A2 | Xanthine derivatives and their preparation and pharmaceutical formulation | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-05-10 | — | — | EP | claimed |
| JP-1238583-A | — | — | None | — | — | JP | disclosed |
| US-4960773-A | ANTITUSSIVE AGENT | CHINOIN GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1990-10-02 | — | — | US | disclosed |
| EP-0268585-B1 | TERTIARY HYDROXYALKYLXANTHINES, THEIR MANUFACTURING PROCESS, MEDICINES CONTAINING THEM AND USE THEREOF | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| JP-H01238583-A | NEW XANTHINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | CHINOIN GYOGYSZER V T G RT | 1989-09-22 | — | — | JP | disclosed |
| US-4833146-A | BRAINS, BLOOD DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0315401-A2 | Xanthine derivatives and their preparation and pharmaceutical formulation | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-05-10 | — | — | EP | disclosed |
| EP-0268585-A1 | TERTIARY HYDROXYALKYLXANTHINES, THEIR MANUFACTURING PROCESS, MEDICINES CONTAINING THEM AND USE THEREOF. | HOECHST AG (DE) | 1988-06-01 | — | — | EP | disclosed |
| WO-1987000523-A2 | TERTIARY HYDROXYALKYLXANTHINES, THEIR MANUFACTURING PROCESS, MEDICINES CONTAINING THEM AND USE THEREOF | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-01-29 | — | — | WO | disclosed |