Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tamoxifen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 8/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tamoxifen SCHEMBL5328781 | 1.00 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL6365 | 1.00 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL178086 | 1.00 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL26077 | 1.00 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL17164701 | 1.00 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL4019370 | 1.00 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL7744729 | 0.98 | ESR1 (0.96) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL5322913 | 0.97 | ESR1 (0.94) | ESR1ESR2MEN1TP53KMT2A | |
| SCHEMBL4104443 | 0.94 | ESR1 (0.89) | ESR1ESR2MEN1TP53KMT2A | |
| Toremifene SCHEMBL21464516 | 0.93 | ESR1 (0.87) | ESR1ESR2MEN1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401243-A1 | MEDICINAL PREPARATIONS CHARACTERIZED BY A COMBINATION OF CYTOSTATIC AGENTS, HORMONAL THERAPEUTIC AGENTS AND PHOSPHONE DERIVATIVES. | HENKEL KGAA (DE) | 1990-12-12 | — | — | EP | disclosed |
| WO-1989007453-A1 | MEDICINAL PREPARATIONS CHARACTERIZED BY A COMBINATION OF CYTOSTATIC AGENTS, HORMONAL THERAPEUTIC AGENTS AND PHOSPHONE DERIVATIVES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1989-08-24 | — | — | WO | disclosed |