Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tamoxifen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 8/20 | 0.94 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.94 |
| ▸ | MEN1 | O00255 | 4/20 | 0.94 |
| ▸ | TP53 | P04637 | 4/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.94 |
| ▸ | GMNN | O75496 | 1/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.94 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.94 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.94 |
| ▸ | THPO | P40225 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tamoxifen SCHEMBL26077 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL5328781 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL10336277 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL6365 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL17164701 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL4019370 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL178086 | 0.97 | ESR1 (1.00) | ESR1ESR2MEN1TP53KMT2A | |
| Tamoxifen SCHEMBL7744729 | 0.95 | ESR1 (0.96) | ESR1ESR2MEN1TP53KMT2A | |
| SCHEMBL4104443 | 0.91 | ESR1 (0.89) | ESR1ESR2MEN1TP53KMT2A | |
| Toremifene SCHEMBL21464516 | 0.91 | ESR1 (0.87) | ESR1ESR2MEN1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007128672-A1 | SUBSTITUTED HEXAHYDRO-1,4-DIAZEPIN-5-ONES AND COMPOSITIONS STABILIZED THEREWITH | CIBA HOLDING INC. (CH) | 2007-11-15 | — | — | WO | disclosed |
| US-20070256352-A1 | Substituted hexahydro-1,4-diazepin-5-ones and compositions stabilized therewith | WOOD MERVIN G | 2007-11-08 | — | — | US | disclosed |
| US-6902695-B2 | Stabilizer combination for the rotomolding process | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| CN-1196740-C | Stabilizer composition for rotational moulding | CIBA SC HOLDING AG (CH) | 2005-04-13 | — | — | CN | disclosed |
| US-20040210056-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA SPECIALTY CHEMICALS CORP. | 2004-10-21 | — | — | US | disclosed |
| US-20040152807-A1 | Stabilizer combination for the rotomolding process | STADLER URS LEO (US) | 2004-08-05 | — | — | US | disclosed |
| US-20020156162-A1 | Stabilizer combination for the rotomolding process | STADLER URS LEO (US) | 2002-10-24 | — | — | US | disclosed |
| US-6444733-B1 | USING STABILIZER MIXTURE | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-09-03 | — | — | US | disclosed |
| CN-1269378-A | Stabilizer composition for rotational moulding | CIBA SC HOLDING AG (CH) | 2000-10-11 | — | — | CN | disclosed |
| EP-1038912-A2 | High molecular weight hindered hydrocarbyloxyamine stabilizers | Ciba SC Holding AG (CH) | 2000-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070256352-A1 | Substituted hexahydro-1,4-diazepin-5-ones and compositions stabilized therewith | CRY1, GPX4, CAND1 | ESR1 3222/4885ESR2 2426/4885MEN1 1833/4885 |
| US-20040210056-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | HRH3, CCNH, H1-2 | ESR1 3149/4885ESR2 2151/4885MEN1 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.