Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746179 | 1.00 | HDAC4 (0.40) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL10337105 | 1.00 | HDAC4 (0.40) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL7354951 | 0.84 | HDAC4 (0.42) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL7354944 | 0.84 | HDAC4 (0.42) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL9079107 | 0.84 | HDAC4 (0.42) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL9079109 | 0.84 | HDAC4 (0.42) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL10557110 | 0.80 | HRH3 (0.39) | EPHX1CTSKKMT2A | |
| SCHEMBL10789387 | 0.78 | EPHX1 (0.34) | EPHX1GAACA1CA2 | |
| SCHEMBL9011358 | 0.78 | HDAC4 (0.40) | HDAC4HDAC1HDAC6EPHX1REN | |
| SCHEMBL10408002 | 0.78 | CTSK (0.41) | HDAC4HDAC1HDAC6EPHX1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |