Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 11/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.55 |
| ▸ | PRKDC | P78527 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12710082 | 0.84 | PIK3CG (0.66) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL10499 | 0.74 | PIK3CG (0.44) | PIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL10447 | 0.74 | PIK3CG (0.45) | PIK3CGPIK3CAPIK3CD | |
| SCHEMBL1702304 | 0.71 | PIK3CG (1.00) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL10361 | 0.71 | PIK3CG (0.49) | PIK3CGPIK3CACYP2C9PIK3CD | |
| SCHEMBL1303665 | 0.71 | MAP3K5 (0.52) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL10369 | 0.71 | CYP1A2 (0.56) | PIK3CGPIK3CACYP2C9 | |
| SCHEMBL12991181 | 0.70 | PIK3CG (0.65) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL12710135 | 0.69 | PIK3CG (0.49) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL13256666 | 0.69 | PIK3CG (0.49) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041634-A1 | PYRAZOLE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-07 | — | — | WO | disclosed |