Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10565006 | 0.85 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10566516 | 0.81 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10565535 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10564671 | 0.76 | MAPT (0.57) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10566796 | 0.76 | MAPT (0.57) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL12953800 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10568592 | 0.74 | KDM4E (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10569385 | 0.73 | KDM4E (0.66) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL15657910 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2THRB | |
| SCHEMBL10568294 | 0.72 | TSHR (0.50) | KDM4EALDH1A1MAPTTHRBKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2256669-A | — | — | None | — | — | JP | disclosed |
| JP-H02256669-A | PRODUCTION OF PYRIMIDINONE COMPOUND | FUJISAWA PHARMACEUT CO LTD | 1990-10-17 | — | — | JP | disclosed |
| US-4824851-A | Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular vasodilator and anti-platelet agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0123402-B1 | PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4746664-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-24 | — | — | US | disclosed |
| US-4612376-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0123402-A2 | Pyrimidine derivatives, preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |