Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.95 |
| ▸ | TSHR | P16473 | 3/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.95 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.95 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340107 | 1.00 | SIGMAR1 (0.95) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| SCHEMBL29766818 | 0.97 | SIGMAR1 (1.00) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| SCHEMBL7218504 | 0.97 | SIGMAR1 (1.00) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| SCHEMBL7218502 | 0.97 | SIGMAR1 (1.00) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| SCHEMBL11610023 | 0.97 | SIGMAR1 (1.00) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL10340142 | 0.96 | SIGMAR1 (0.98) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL10340144 | 0.96 | SIGMAR1 (0.98) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL14809487 | 0.95 | SIGMAR1 (0.95) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| SCHEMBL11248186 | 0.90 | SIGMAR1 (0.81) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 | |
| SCHEMBL10833026 | 0.89 | SIGMAR1 (0.76) | SIGMAR1CYP3A4CYP2D6TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248824-B1 | USE OF CIS-N-(2 AMINOCYCLOALIPHATIC) BENZENE ACETAMIDE AND BENZAMIDE FOR THE MANUFACTURE OF ANTICONVULSANTS | THE UPJOHN COMPANY (US) | 1990-01-17 | — | — | EP | claimed |
| EP-0248824-A1 | Use of CIS-N-(2 Aminocycloaliphatic) benzene acetamide and Benzamide for the manufacture of anticonvulsants. | UPJOHN CO (US) | 1987-12-16 | — | — | EP | claimed |
| EP-0222533-A1 | Cis-N-[(2-aminocycloaliphatic)benzene acetamide and -benzamide anticonvulsants | THE UPJOHN COMPANY (US) | 1987-05-20 | — | — | EP | claimed |
| WO-1987002584-A1 | CIS-N-(2-AMINOCYCLOALIPHATIC)BENZENE ACETAMIDE AND -BENZAMIDE ANTICONVULSANTS | THE UPJOHN COMPANY (US) | 1987-05-07 | — | — | WO | claimed |
| EP-0248824-B1 | USE OF CIS-N-(2 AMINOCYCLOALIPHATIC) BENZENE ACETAMIDE AND BENZAMIDE FOR THE MANUFACTURE OF ANTICONVULSANTS | THE UPJOHN COMPANY (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0248824-A1 | Use of CIS-N-(2 Aminocycloaliphatic) benzene acetamide and Benzamide for the manufacture of anticonvulsants. | UPJOHN CO (US) | 1987-12-16 | — | — | EP | disclosed |
| WO-1987002584-A1 | CIS-N-(2-AMINOCYCLOALIPHATIC)BENZENE ACETAMIDE AND -BENZAMIDE ANTICONVULSANTS | THE UPJOHN COMPANY (US) | 1987-05-07 | — | — | WO | disclosed |