Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Zaltidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 11/20 | 0.38 |
| ▸ | ATP4B | P51164 | 11/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zaltidine SCHEMBL10340389 | 1.00 | ATP4A (0.38) | ATP4AATP4BABL1MEN1KMT2A | |
| Zaltidine SCHEMBL3605309 | 0.99 | ATP4A (0.39) | ATP4AATP4BABL1MEN1KMT2A | |
| Zaltidine SCHEMBL9371241 | 0.97 | ATP4A (0.38) | ATP4AATP4BABL1MEN1KMT2A | |
| SCHEMBL10859494 | 0.83 | ATP4A (0.35) | ATP4AATP4BABL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10972462 | 0.82 | MAPT (0.36) | ATP4AATP4BABL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10978743 | 0.82 | MAPT (0.36) | ATP4AATP4BABL1MEN1KMT2A | |
| Bromide SCHEMBL10859506 | 0.81 | ATP4A (0.35) | ATP4AATP4BABL1 | |
| SCHEMBL10858261 | 0.80 | ATP4A (0.35) | ATP4AATP4BABL1 | |
| Hydrochloric Acid SCHEMBL11032190 | 0.78 | ATP4A (0.38) | ATP4AATP4BABL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10974350 | 0.78 | TYR (0.36) | ATP4AATP4BABL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178121-B1 | IMPROVED FORMULATION OF ANTIINFLAMMATORY DRUGS | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |
| EP-0178822-B1 | 2-GUANIDINO-4-(2-METHYL-4-IMIDAZOLYL)THIAZOLES IN THE TREATMENT OF RHEUMATOID ARTHRITIS | PFIZER INC. (US) | 1990-01-17 | — | — | EP | disclosed |
| US-4636498-A | OXICAMS, ANTIULCER, ANTISECRETORY 2-GUANIDINO-4-(4-IMIDAZOLYL) THIAZOLES | PFIZER INC. (US) | 1987-01-13 | — | — | US | disclosed |
| US-4632993-A | Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide | PFIZER INC. (US) | 1986-12-30 | — | — | US | disclosed |
| US-4591595-A | 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis | PFIZER INC. (US) | 1986-05-27 | — | — | US | disclosed |
| US-4590299-A | 2-guanidino-4-heteroarylthiazoles | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0178822-A2 | 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis | PFIZER INC. (US) | 1986-04-23 | — | — | EP | disclosed |
| EP-0178123-A2 | 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole dihydrobromide and process therefor | PFIZER INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4510313-A | 2-Guanidino-4-heteroarylthiazoles | PFIZER INC. (US) | 1985-04-09 | — | — | US | disclosed |
| EP-0050458-B1 | 2-GUANIDINO-4-HETEROARYLTHIAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1985-01-02 | — | — | EP | disclosed |
| US-4452987-A | Haloacetyl imidazoles | PFIZER INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4374843-A | 2-Guanidino-4-heteroarylthiazoles | PFIZER INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0050458-A2 | 2-Guanidino-4-heteroarylthiazoles and pharmaceutical compositions containing them | PFIZER INC. (US) | 1982-04-28 | — | — | EP | disclosed |