ATP4A

Potassium-transporting ATPase alpha chain 1 ( · P20648 · ATP4A on Sugi Atlas →

25,590 patent compounds predicted against ATP4A, 11,641 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Bromide (SCHEMBL825891)	1.00	20/20
SCHEMBL729163	0.58	20/20
SCHEMBL823907	1.00	19/20
Hydrochloric Acid (SCHEMBL826477)	1.00	19/20
Bromide (SCHEMBL825847)	0.97	19/20
Hydrochloric Acid (SCHEMBL827560)	0.91	19/20
Hydrochloric Acid (SCHEMBL826833)	0.75	19/20
Bromide (SCHEMBL826782)	0.69	19/20
Bromide (SCHEMBL826966)	0.68	19/20
Bromide (SCHEMBL826037)	0.67	19/20
Bromide (SCHEMBL826017)	1.00	18/20
Bromide (SCHEMBL826537)	1.00	18/20
Bromide (SCHEMBL827268)	1.00	18/20
Bromide (SCHEMBL826517)	0.73	18/20
Bromide (SCHEMBL826740)	0.73	18/20
Bromide (SCHEMBL826727)	0.72	18/20
Bromide (SCHEMBL826907)	0.72	18/20
Bromide (SCHEMBL827200)	0.70	18/20
Hydrochloric Acid (SCHEMBL827736)	0.68	18/20
Hydrochloric Acid (SCHEMBL826973)	0.66	18/20

Clinical trials — most relevant to ATP4A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes	PHASE4	UNKNOWN
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
PHOspholamban RElated CArdiomyopathy STudy - Intervention	PHASE3	COMPLETED
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels	PHASE3	COMPLETED
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Copper Histidine Therapy for Menkes Diseases	PHASE1/PHASE2	COMPLETED
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.	nan	NOT_YET_RECRUITING
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING
Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson Disease	nan	RECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Pharmacogenetics and Cardiovascular Events	nan	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ATP4A binder may also engage these)

Protein	Name	Similarity
Q64436	—	1.000	Q64436 →
P09626	—	1.000	P09626 →
P27112	—	1.000	P27112 →
P50996	—	1.000	P50996 →
P19156	—	1.000	P19156 →
Q92126	—	0.996	Q92126 →
Q9TV52	—	0.995	Q9TV52 →
P09572	—	0.995	P09572 →
P54708	—	0.995	P54708 →
O77696	—	0.995	O77696 →
Q9YH26	—	0.994	Q9YH26 →
P35316	—	0.994	P35316 →
Q9WV27	—	0.994	Q9WV27 →
ATP2A1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0.994	landscape →
Q07421	—	0.993	Q07421 →
ATP2A3	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0.993	landscape →
Q03669	—	0.993	Q03669 →
Q92123	—	0.993	Q92123 →
Q9YGL9	—	0.993	Q9YGL9 →
Q9M2L4	—	0.993	Q9M2L4 →
P06685	—	0.992	P06685 →
Q7ZW18	—	0.992	Q7ZW18 →
Q0VCY0	—	0.992	Q0VCY0 →
O81108	—	0.991	O81108 →
Q2QMX9	—	0.991	Q2QMX9 →
Q6PIE5	—	0.991	Q6PIE5 →
O46674	—	0.991	O46674 →
P25489	—	0.991	P25489 →
P05025	—	0.991	P05025 →
Q92105	—	0.990	Q92105 →