Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036948 | 0.88 | SMN1; SMN2 (0.34) | MEN1PKMKMT2APDE4BMAPT | |
| SCHEMBL29508372 | 0.82 | TLR8 (0.40) | PDE4BLMNANPSR1SMN1; SMN2LRRK2 | |
| SCHEMBL23924927 | 0.79 | LRRK2 (0.38) | MEN1PKMKMT2APDE4BMAPT | |
| SCHEMBL23924929 | 0.79 | LRRK2 (0.38) | MEN1PKMKMT2APDE4BMAPT | |
| SCHEMBL5270377 | 0.79 | LRRK2 (0.38) | MEN1PKMKMT2AMAPTTP53 | |
| SCHEMBL28888309 | 0.77 | MEN1 (0.46) | MEN1PKMKMT2APDE4BLMNA | |
| SCHEMBL28674921 | 0.76 | TLR8 (0.41) | MEN1PKMKMT2ALRRK2 | |
| SCHEMBL29508394 | 0.76 | TLR8 (0.41) | MEN1PKMKMT2ALRRK2 | |
| SCHEMBL23924991 | 0.75 | LRRK2 (0.36) | MEN1PKMKMT2AMAPTKDM4E | |
| SCHEMBL23924989 | 0.75 | LRRK2 (0.36) | MEN1PKMKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386557-A1 | Novel substituted imidazoquinolines | 4SC AG (DE) | 2011-11-16 | — | — | EP | disclosed |
| US-8040157-B2 | Digital circuits with adaptive resistance to single event upset | RAYTHEON COMPANY (US) | 2011-10-18 | — | — | US | disclosed |
| EP-2276486-A2 | NOVEL SUBSTITUTED IMIDAZOQUINOLINES | 4SC AG (DE) | 2011-01-26 | — | — | EP | disclosed |