SCHEMBL10341869

SCHEMBL10341869

Cc1c(F)c(F)c(NC(C(=O)O)C(C)C)c(Cl)c1F

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 7/20 0.38
TAS1R1 Q7RTX1 7/20 0.38
TAS1R2 Q8TE23 7/20 0.38
MAPT P10636 2/20 0.37
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 2/20 0.32
MMP2 P08253 3/20 0.32
MMP1 P03956 2/20 0.32
MMP3 P08254 2/20 0.32
MMP7 P09237 2/20 0.32
MMP9 P14780 2/20 0.32
MMP13 P45452 2/20 0.32
MAPK1 P28482 1/20 0.32
TSHR P16473 1/20 0.32
SDCBP O00560 1/20 0.31
SDC2 P34741 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11203247 0.79 MAPK1 (0.38) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL11203244 0.79 MAPK1 (0.38) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL10341842 0.79 MEN1 (0.37) TAS1R3TAS1R1TAS1R2
SCHEMBL11196349 0.71 MMP2 (0.39) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL11196347 0.71 MMP2 (0.39) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL29381571 0.70 MAPT (0.38) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL11195097 0.70 MAPT (0.40) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL29382348 0.70 MAPT (0.38) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL11195100 0.70 MAPT (0.40) MAPTKDM4EALDH1A1MMP2MMP1
SCHEMBL10957011 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0181284-B1 AMINO ACID ESTERS SANDOZ AG (CH) 1990-02-07 EP claimed
EP-0083437-A2 Stable oil-in-water dispersions SANDOZ AG (CH) 1983-07-13 EP claimed
EP-0181284-B1 AMINO ACID ESTERS SANDOZ AG (CH) 1990-02-07 EP disclosed
EP-0181284-A1 Amino acid esters SANDOZ AG (CH) 1986-05-14 EP disclosed
EP-0038617-B1 DIASTEREOMERS OF AMINO ACID ESTERS, PESTICIDAL COMPOSITIONS INCLUDING THEM AND METHOD OF CONTROLLING PESTS USING THEM ZOECON CORPORATION (US) 1983-07-20 EP disclosed