MMP2

72 kDa type IV collagenase · P08253 · MMP2 on Sugi Atlas →

422,731 patent compounds predicted against MMP2, 251,821 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL34604	1.00	17/20
Ilomastat (SCHEMBL35303)	1.00	16/20
SCHEMBL32038	0.55	10/20
Marimastat (SCHEMBL34033)	1.00	8/20
Batimastat (SCHEMBL4332)	1.00	7/20
Batimastat (SCHEMBL4333)	1.00	7/20
SCHEMBL26434	0.57	7/20
Foscarnet (SCHEMBL7637)	0.37	7/20
Phenobarbital (SCHEMBL16583)	0.80	6/20
SCHEMBL24140	0.56	6/20
Sulfluramid (SCHEMBL26873)	0.55	6/20
SCHEMBL23932	0.54	6/20
SCHEMBL5990	0.43	6/20
Epigalocatechin Gallate (SCHEMBL35258)	1.00	5/20
SCHEMBL25130	0.47	5/20
SCHEMBL26986	0.47	5/20
Nogalamycin (SCHEMBL4472)	0.38	5/20
Nogalamycin (SCHEMBL4473)	0.38	5/20
Tiludronic Acid (SCHEMBL18988)	1.00	4/20
Primidone (SCHEMBL34221)	0.56	4/20

Clinical trials — most relevant to MMP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Doxycycline In Lymphangioleiomyomatosis (LAM)	PHASE4	COMPLETED
The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®	PHASE2/PHASE3	COMPLETED
Non-US Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease	PHASE3	COMPLETED
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis	PHASE2	COMPLETED
A Phase 2, Randomized, Double-blind, Placebo Controlled Dose Ranging Study of Repeat Doses of AA4500 for the Treatment of Edematous Fibrosclerotic Panniculopathy	PHASE2	COMPLETED
Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand	PHASE1/PHASE2	COMPLETED
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma	PHASE2	UNKNOWN
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer	PHASE1	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries	nan	RECRUITING
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar	nan	COMPLETED
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity	nan	WITHDRAWN
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
Matrix Metalloproteinase (MMP) in Heart Failure	nan	COMPLETED
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus	nan	COMPLETED
Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation	nan	COMPLETED
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia	nan	UNKNOWN
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Periodontal Health in Post COVID-19 Patients	nan	UNKNOWN
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Peri-implantitis and MMP-8	nan	COMPLETED
Salivary Markers in Periodontal Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MMP2 binder may also engage these)

Protein	Name	Similarity
P50757	—	1.000	P50757 →
Q9GLE5	—	1.000	Q9GLE5 →
P33434	—	1.000	P33434 →
P33436	—	1.000	P33436 →
Q90611	—	1.000	Q90611 →
P53690	—	1.000	P53690 →
P41245	—	0.999	P41245 →
MMP14	Matrix metalloproteinase-14	0.998	landscape →
Q95220	—	0.998	Q95220 →
Q10739	—	0.997	Q10739 →
P52176	—	0.997	P52176 →
Q5RES1	—	0.997	Q5RES1 →
P07152	—	0.997	P07152 →
O55123	—	0.996	O55123 →
MMP1	Interstitial collagenase	0.996	landscape →
Q10835	—	0.996	Q10835 →
Q9GLE4	—	0.996	Q9GLE4 →
Q6Y4Q5	—	0.996	Q6Y4Q5 →
P57748	—	0.996	P57748 →
O18767	—	0.996	O18767 →
Q28397	—	0.995	Q28397 →
P03957	—	0.995	P03957 →
MMP3	Stromelysin-1	0.995	landscape →
MMP9	Matrix metalloproteinase-9	0.995	landscape →
P28053	—	0.995	P28053 →
O88766	—	0.995	O88766 →
Q9WTR0	—	0.995	Q9WTR0 →
O70138	—	0.994	O70138 →
Q9XT90	—	0.994	Q9XT90 →
P41246	—	0.994	P41246 →