Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | CCR8 | P51685 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10343487 | 0.87 | KDM4E (0.47) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL10343456 | 0.83 | KDM4E (0.44) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL10343307 | 0.83 | KDM4E (0.44) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL10383459 | 0.82 | KDM4E (0.42) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL10343515 | 0.82 | KDM4E (0.42) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL9336005 | 0.81 | KDM4E (0.61) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL3115391 | 0.79 | KDM4E (0.52) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL10343340 | 0.78 | KDM4E (0.47) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL10383767 | 0.78 | KDM4E (0.47) | KDM4EGAATDP1LMNACCR1 | |
| SCHEMBL8159573 | 0.76 | KDM4E (0.48) | KDM4EGAATDP1LMNACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198696-B1 | PHOSPHINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4902675-A | ANTITUMOR AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0198696-A2 | Phosphine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1986-10-22 | — | — | EP | disclosed |