Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033805 | 0.84 | NR4A2 (0.47) | NR4A2GABRA1GABRA3GABRB1GABRB2 | |
| SCHEMBL28229874 | 0.82 | NR4A2 (0.35) | NR4A2 | |
| SCHEMBL28046327 | 0.81 | NR4A2 (0.49) | NR4A2GPR84 | |
| SCHEMBL1033378 | 0.80 | NR4A2 (0.38) | NR4A2GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL17417627 | 0.78 | F7 (0.46) | GPR84 | |
| SCHEMBL5592328 | 0.78 | NR4A2 (0.49) | NR4A2 | |
| SCHEMBL27893657 | 0.76 | GABRA1 (0.38) | NR4A2GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL27890213 | 0.73 | NR4A2 (0.44) | NR4A2 | |
| SCHEMBL15557355 | 0.72 | KDM4E (0.54) | NR4A2GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL6986880 | 0.72 | NR4A2 (0.72) | NR4A2GABRA1GABRA3GABRB1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276731-A1 | 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 | Boehringer Ingelheim International GmbH (DE) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009126675-A1 | 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |