Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.54 |
| ▸ | CDK1 | P06493 | 5/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.52 |
| ▸ | CDK4 | P11802 | 4/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.52 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | BCL6 | P41182 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032136 | 0.99 | SMN1; SMN2 (0.62) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL3620677 | 0.99 | SMN1; SMN2 (0.62) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL3654146 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL12955857 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL1033717 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL1032622 | 0.88 | MAPK10 (0.49) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL1031594 | 0.86 | EIF2AK2 (0.59) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL1031173 | 0.85 | AGER (0.54) | SMN1; SMN2EIF2AK2MAPK8MAPK9MAPK10 | |
| SCHEMBL1032761 | 0.85 | IKBKB (0.49) | SMN1; SMN2MAPK8MAPK9MAPK10CDK1 | |
| SCHEMBL1031273 | 0.83 | HDAC8 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | claimed |
| WO-2011008931-A2 | ARYLPYRIMIDINE COMPOUNDS AND COMBINATION THERAPY COMPRISING SAME FOR TREATING CYSTIC FIBROSIS & RELATED DISORDERS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |