SCHEMBL10345351

SCHEMBL10345351

CCCCC[C@H]1CC[C@H]([C@H]2CC[C@H](CCc3ccc(C#N)c(F)c3)CC2)CC1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.40
TRPV4 Q9HBA0 1/20 0.36
KDM1A O60341 9/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C8 P10632 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
S1PR3 Q99500 1/20 0.35
KCNJ1 P48048 1/20 0.35
KCNH2 Q12809 1/20 0.35
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
AOC3 Q16853 1/20 0.34
AR P10275 2/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
CTSK P43235 1/20 0.33
CTSC P53634 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10345350 1.00 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9620711 1.00 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9620590 0.99 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9620713 0.99 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9621160 0.99 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9621129 0.99 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9620741 0.99 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9620771 0.96 DAO (0.41) DAOTRPV4KDM1AKCNJ1KCNH2
SCHEMBL9620739 0.96 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8
SCHEMBL9620737 0.96 DAO (0.40) DAOTRPV4KDM1ACYP3A4CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4917819-A Cyclohexane derivative and liquid crystal composition containing same CHISSO CORPORATION (JP) 1990-04-17 US disclosed
EP-0205998-B1 CYCLOHEXANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CONTAINING SAME Chisso Corporation (JP) 1990-02-28 EP disclosed
US-4797228-A Cyclohexane derivative and liquid crystal composition containing same CHISSO CORPORATION (JP) 1989-01-10 US disclosed
EP-0205998-A1 Cyclohexane derivative and liquid crystal composition containing same Chisso Corporation (JP) 1986-12-30 EP disclosed