SCHEMBL9620737

SCHEMBL9620737

CCCCC[C@H]1CC[C@H](CCc2ccc(C#N)c(F)c2)CC1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.40
TRPV4 Q9HBA0 1/20 0.39
CYP3A4 P08684 1/20 0.37
CYP2C8 P10632 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
S1PR3 Q99500 1/20 0.37
KCNJ1 P48048 1/20 0.37
KCNH2 Q12809 1/20 0.37
KDM1A O60341 8/20 0.37
AOC3 Q16853 1/20 0.36
AR P10275 2/20 0.35
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9620739 1.00 DAO (0.40) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9621143 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9620840 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9621147 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9620837 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9621197 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL10479788 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9621081 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9621201 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6
SCHEMBL9620580 0.99 DAO (0.39) DAOTRPV4CYP3A4CYP2C8CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0283490-B1 PROCESS FOR THE PRODUCTION OF ETHANE DERIVATIVES MERCK PATENT GmbH (DE) 1992-01-08 EP disclosed
EP-0338054-A1 CROSS COUPLING OF TITANIUM ORGANYLS MERCK PATENT GmbH (DE) 1989-10-25 EP disclosed
WO-1989003812-A1 CROSS COUPLING OF TITANIUM ORGANYLS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1989-05-05 WO disclosed
EP-0283490-A1 PROCESS FOR THE PRODUCTION OF ETHANE DERIVATIVES. MERCK PATENT GMBH (DE) 1988-09-28 EP disclosed
EP-0282542-A1 PROCESS FOR THE PRODUCTION OF ALKYLENE OR CYCLICALLY LINKED COMPOUNDS. MERCK PATENT GMBH (DE) 1988-09-21 EP disclosed
WO-1988002357-A2 PROCESS FOR THE PRODUCTION OF ALKYLENE OR CYCLICALLY LINKED COMPOUNDS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1988-04-07 WO disclosed
WO-1988002364-A2 PROCESS FOR THE PRODUCTION OF ETHANE DERIVATIVES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1988-04-07 WO disclosed