Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 3/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.53 |
| ▸ | CDK1 | P06493 | 4/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.53 |
| ▸ | CCND1 | P24385 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033093 | 0.87 | IKBKB (0.52) | EIF2AK2IKBKBCDK1CCNB1CDK4 | |
| SCHEMBL1033097 | 0.85 | MKNK1 (0.57) | EIF2AK2PIK3CAPIK3CBPIK3CGCDK1 | |
| SCHEMBL1033843 | 0.85 | HDAC8 (0.56) | EIF2AK2IKBKBCDK1CCNB1CDK4 | |
| SCHEMBL5818203 | 0.84 | EIF2AK2 (0.49) | EIF2AK2IKBKBCDK1CCNB1CDK4 | |
| SCHEMBL5817943 | 0.83 | EIF2AK2 (0.50) | EIF2AK2IKBKBPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1034820 | 0.82 | CDK4 (0.57) | IKBKBCDK1CCNB1CDK4CCNA2 | |
| SCHEMBL1032138 | 0.82 | IKBKB (0.76) | EIF2AK2IKBKBPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1033987 | 0.82 | IKBKB (0.56) | IKBKBCDK1CCNB1CDK4CCNA2 | |
| SCHEMBL1029919 | 0.82 | IKBKB (0.57) | IKBKBCDK1CCNB1CDK4CCNA2 | |
| SCHEMBL1034404 | 0.82 | CDK1 (0.51) | EIF2AK2IKBKBCDK1CCNB1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | claimed |
| WO-2011008931-A2 | ARYLPYRIMIDINE COMPOUNDS AND COMBINATION THERAPY COMPRISING SAME FOR TREATING CYSTIC FIBROSIS & RELATED DISORDERS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |