Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GALR2 | O43603 | 1/20 | 0.51 |
| ▸ | GALR1 | P47211 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030948 | 0.87 | CDK1 (0.49) | MKNK1EIF2AK2MKNK2CCNA2CDK2 | |
| SCHEMBL1029832 | 0.87 | CDK1 (0.49) | MKNK1EIF2AK2MKNK2CCNA2CDK2 | |
| SCHEMBL1032945 | 0.87 | CDK1 (0.49) | MKNK1EIF2AK2MKNK2CCNA2CDK2 | |
| SCHEMBL1029427 | 0.87 | ALOX5 (0.49) | MKNK1EIF2AK2MKNK2CCNA2CDK2 | |
| SCHEMBL1034547 | 0.85 | EIF2AK2 (0.58) | EIF2AK2DYRK1ACLK4DYRK1BCLK1 | |
| SCHEMBL1032105 | 0.84 | MAPT (0.46) | MKNK1EIF2AK2DYRK1ACLK4DYRK1B | |
| SCHEMBL1034404 | 0.83 | CDK1 (0.51) | MKNK1EIF2AK2MKNK2CCNA2CDK2 | |
| SCHEMBL1033626 | 0.81 | CDK1 (0.53) | MKNK2CCNA2CDK2MAPK1PIK3CA | |
| SCHEMBL1028968 | 0.81 | MAP4K4 (0.55) | MKNK2CCNA2CDK2MAPK3MAPK1 | |
| SCHEMBL1030530 | 0.81 | ADORA1 (0.59) | EIF2AK2MKNK2CCNA2CDK2MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | claimed |
| WO-2011008931-A2 | ARYLPYRIMIDINE COMPOUNDS AND COMBINATION THERAPY COMPRISING SAME FOR TREATING CYSTIC FIBROSIS & RELATED DISORDERS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |