Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 13/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | THPO | P40225 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345626 | 0.85 | HSP90AA1 (0.38) | DRD1HSD17B10THPOMAPK1HIF1A | |
| SCHEMBL10345766 | 0.80 | DRD1 (0.50) | DRD1DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL10345623 | 0.79 | DRD1 (0.54) | DRD1HSD17B10THPOMAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL10345710 | 0.78 | DRD1 (0.62) | DRD1HSD17B10THPOMAPK1HIF1A | |
| SCHEMBL10345415 | 0.76 | MTNR1B (0.47) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10345943 | 0.75 | DRD1 (0.73) | DRD1HSD17B10THPOMAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL10345672 | 0.74 | DRD1 (0.74) | DRD1HSD17B10THPOMAPK1HIF1A | |
| SCHEMBL10746813 | 0.70 | CYP3A4 (0.54) | DRD1HSD17B10THPOMAPK1HIF1A | |
| SCHEMBL10345859 | 0.67 | CYP2D6 (0.53) | DRD1HSD17B10THPOMAPK1HIF1A | |
| SCHEMBL10749624 | 0.66 | CYP3A4 (0.38) | DRD1SMN1; SMN2DRD5CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230755-B1 | 1-PHENYL-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0230755-A1 | 1-Phenyl-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-05 | — | — | EP | disclosed |