MTNR1B — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ramelteon (SCHEMBL29237)	1.00	20/20
SCHEMBL123962	1.00	20/20
SCHEMBL124885	1.00	20/20
SCHEMBL125264	1.00	20/20
SCHEMBL126984	0.82	20/20
SCHEMBL127176	0.69	20/20
SCHEMBL124323	0.67	20/20
SCHEMBL126737	0.67	20/20
SCHEMBL124849	0.65	20/20
SCHEMBL126410	0.65	20/20
SCHEMBL125427	0.52	20/20
SCHEMBL124618	0.51	20/20
SCHEMBL124983	1.00	19/20
SCHEMBL125268	1.00	19/20
SCHEMBL126117	0.71	19/20
SCHEMBL125365	0.68	19/20
SCHEMBL127156	0.68	19/20
SCHEMBL123405	0.67	19/20
SCHEMBL127145	0.66	19/20
SCHEMBL125422	0.58	19/20

Clinical trials — most relevant to MTNR1B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study on the Efficacy of Agomelatine Combined With Antipsychotics to Treat Negative Symptoms in Schizophrenia	PHASE4	UNKNOWN
The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment	PHASE4	COMPLETED
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers	PHASE4	COMPLETED
Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene	PHASE3	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Acute Metabolic Effects of Melatonin Treatment	PHASE1/PHASE2	COMPLETED
Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19	PHASE2	UNKNOWN
Metabolic Effects of Melatonin Treatment	PHASE1	COMPLETED
Melatonin Osteoporosis Prevention Study	PHASE1	COMPLETED
Glucose Tolerance, Meal Timing and MTNR1B	nan	COMPLETED
MTNR1B SNP*Food Timing Interaction on Glucose Control	nan	COMPLETED
Shift Work, Heredity, Insulin, and Food Timing Study	nan	COMPLETED
Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2	nan	COMPLETED
Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1	nan	COMPLETED
Meal Timing, Genetics and Weight Loss	nan	RECRUITING
Melatonin Levels and the Relation to Obesity and the Metabolic Syndrome in Children and Adolescents	nan	COMPLETED
Interaction of MTNR1B Genotype and Type of Breakfast (Protein-enriched v Carbohydrate-rich) on Postprandial Glucose Response.	nan	COMPLETED
Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department	nan	UNKNOWN
Melatonin Receptor Agonist and Peripheral Biological Markers	nan	COMPLETED
A Personalized Program of Physical Activity and Diet for Hypothalamic Obesity	nan	COMPLETED
Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy	nan	NOT_YET_RECRUITING
Rare Obesity Cohorts With Food Behavioral Disorders : Better Diagnosis for Better Treatment	nan	RECRUITING
Influence of Caffeine Consumption on the Human Circadian System	nan	COMPLETED
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study	nan	COMPLETED
Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery	nan	UNKNOWN
Effect of Therapeutic Light on Sleep, Circadian Rhythm, and Global Function in Women With Alzheimer's	nan	COMPLETED
Registration of Skin-Temperatures and Sleep-Wake Behaviour	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MTNR1B binder may also engage these)

Protein	Name	Similarity
P49287	—	1.000	P49287 →
Q8CIQ6	—	1.000	Q8CIQ6 →
P49288	—	0.996	P49288 →
P48040	—	0.993	P48040 →
MTNR1A	Melatonin receptor type 1A	0.993	landscape →
P51046	—	0.991	P51046 →
P49285	—	0.991	P49285 →
P31387	—	0.989	P31387 →
P49219	—	0.989	P49219 →
Q2KI97	—	0.988	Q2KI97 →
P51049	—	0.988	P51049 →
P30966	—	0.988	P30966 →
Q6XXX9	—	0.988	Q6XXX9 →
P35365	—	0.988	P35365 →
P49217	—	0.987	P49217 →
O70528	—	0.987	O70528 →
Q90456	—	0.987	Q90456 →
Q6XXY0	—	0.986	Q6XXY0 →
Q61184	—	0.986	Q61184 →
GPR84	G-protein coupled receptor 84	0.985	landscape →
P47800	—	0.985	P47800 →
P51050	—	0.984	P51050 →
HTR5A	5-hydroxytryptamine receptor 5A	0.984	landscape →
Q28997	—	0.984	Q28997 →
HTR4	5-hydroxytryptamine receptor 4	0.984	landscape →
P52703	—	0.984	P52703 →
P97288	—	0.983	P97288 →
Q62758	—	0.983	Q62758 →
Q8CIM5	—	0.983	Q8CIM5 →
DRD3	D(3) dopamine receptor	0.983	landscape →