Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYBB | P04839 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.31 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723647 | 0.84 | MAPT (0.43) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL3997603 | 0.82 | MAPT (0.42) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL27389284 | 0.81 | MAPT (0.43) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL2722544 | 0.75 | GAA (0.42) | MAPTGAAP2RX4KMT2ALMNA | |
| SCHEMBL9390020 | 0.72 | MAPT (0.52) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL7328852 | 0.71 | MAPT (0.50) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL4770605 | 0.70 | MAPT (0.45) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL4792080 | 0.70 | MAPT (0.41) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| SCHEMBL30890804 | 0.70 | MAPT (0.41) | MAPTGAAP2RX4SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL15414087 | 0.69 | BIRC2 (0.36) | MAPTGAAP2RX4SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230755-B1 | 1-PHENYL-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0230755-A1 | 1-Phenyl-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-05 | — | — | EP | disclosed |