Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792080 | 0.86 | MAPT (0.41) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Hydrochloric Acid SCHEMBL15414087 | 0.77 | BIRC2 (0.36) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL2723647 | 0.75 | MAPT (0.43) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL15619921 | 0.72 | TAAR1 (0.31) | — | |
| SCHEMBL9390020 | 0.71 | MAPT (0.52) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL10345841 | 0.70 | MAPT (0.42) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL3997603 | 0.70 | MAPT (0.42) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL27389284 | 0.70 | MAPT (0.43) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL7328852 | 0.70 | MAPT (0.50) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL9314943 | 0.67 | GABBR2 (0.49) | MAPTGAAMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12358928-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2025-07-15 | — | — | US | disclosed |
| US-20240150376-A1 | Compounds, Compositions and Methods | DENALI THERAPEUTICS INC. (US) | 2024-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150376-A1 | Compounds, Compositions and Methods | PIK3CA, PLK1, PIK3CB | MAPT 1843/4885GAA 2016/4885RAB9A 2053/4885 |
| US-12358928-B2 | Compounds, compositions and methods | PIK3CA, PLK1, PIK3CB | MAPT 1843/4885GAA 2016/4885RAB9A 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.