Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770774 | 0.88 | HSD11B1 (0.77) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL1771620 | 0.88 | HSD11B1 (0.77) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL1771584 | 0.88 | HSD11B1 (0.77) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL1770776 | 0.88 | HSD11B1 (0.77) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL1770771 | 0.88 | HSD11B1 (0.77) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL1033344 | 0.82 | HSD11B1 (1.00) | HSD11B1CYP2C9 | |
| SCHEMBL1033343 | 0.82 | HSD11B1 (1.00) | HSD11B1CYP2C9 | |
| SCHEMBL1035028 | 0.81 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL1035124 | 0.79 | HSD11B1 (0.76) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 | |
| SCHEMBL15258173 | 0.79 | HSD11B1 (0.76) | HSD11B1CYP2C9CYP3A4CYP2D6HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276730-A2 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009131669-A2 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |