SCHEMBL10346752

SCHEMBL10346752

CC(C)(C=Cc1ccc(Cl)cc1)COCc1cccc(Oc2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.41
PPARA Q07869 1/20 0.41
ALDH1A1 P00352 4/20 0.40
FFAR1 O14842 1/20 0.39
LMNA P02545 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
ADRA2A P08913 1/20 0.39
CNR1 P21554 1/20 0.39
ATM Q13315 1/20 0.39
FFAR4 Q5NUL3 1/20 0.38
DAGLA Q9Y4D2 1/20 0.38
LCK P06239 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP19A1 P11511 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10346750 1.00 PPARG (0.41) PPARGPPARAALDH1A1FFAR1LMNA
SCHEMBL10346768 0.91 TDP1 (0.39) PPARGPPARAALDH1A1FFAR1LMNA
SCHEMBL10346767 0.91 TDP1 (0.39) PPARGPPARAALDH1A1FFAR1LMNA
SCHEMBL10346795 0.90 FFAR1 (0.42) ALDH1A1FFAR1LMNAL3MBTL1TDP1
SCHEMBL10346797 0.90 FFAR1 (0.42) ALDH1A1FFAR1LMNAL3MBTL1TDP1
SCHEMBL10346747 0.89 FFAR1 (0.39) ALDH1A1FFAR1LMNAL3MBTL1TDP1
SCHEMBL10346745 0.89 FFAR1 (0.39) ALDH1A1FFAR1LMNAL3MBTL1TDP1
SCHEMBL10346988 0.88 ALDH1A1 (0.40) PPARGPPARAALDH1A1FFAR1LMNA
SCHEMBL10346990 0.88 ALDH1A1 (0.40) PPARGPPARAALDH1A1FFAR1LMNA
SCHEMBL10346989 0.88 ALDH1A1 (0.40) PPARGPPARAALDH1A1FFAR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0220810-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-05-02 EP claimed
EP-0220810-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-05-06 EP claimed
EP-0220810-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-05-02 EP disclosed
US-4788348-A HYDROXY AROMATIC ETHERS AS CHEMICAL INTERMEDIATES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-11-29 US disclosed
US-4705900-A Insecticidal alkenes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-11-10 US disclosed
EP-0220810-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-05-06 EP disclosed