Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 4/20 | 0.38 |
| ▸ | HTR1B | P28222 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340392 | 0.80 | MTNR1A (0.50) | MTNR1AMTNR1BHTR1DHTR1BMAOA | |
| SCHEMBL23261952 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BHTR1DHTR1BSLC6A4 | |
| SCHEMBL10347545 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BHTR1DHTR1BMAOA | |
| SCHEMBL23261950 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BHTR1DHTR1BMAOA | |
| SCHEMBL10347197 | 0.78 | HTR1D (0.38) | MTNR1AMTNR1BHTR1DHTR1BSLC6A4 | |
| SCHEMBL8891069 | 0.78 | HTR1D (0.46) | HTR1DHTR1BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11036691 | 0.78 | MTNR1A (0.71) | MTNR1AMTNR1BDRD2DRD3 | |
| SCHEMBL8891420 | 0.76 | MTNR1A (0.52) | MTNR1AMTNR1BHTR1DHTR1BMAOA | |
| SCHEMBL7519588 | 0.75 | MTNR1A (0.51) | MTNR1AMTNR1BHTR1DHTR1BSLC6A4 | |
| SCHEMBL23261872 | 0.73 | MEN1 (0.45) | MTNR1AMTNR1BHTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153083-A2 | 6-Substituted-4-dialkylaminotetrahydrobenz(c,d)indoles | ELI LILLY AND COMPANY (US) | 1985-08-28 | — | — | EP | claimed |
| EP-0153083-B1 | 6-SUBSTITUTED-4-DIALKYLAMINOTETRAHYDROBENZ(C,D)INDOLES | ELI LILLY AND COMPANY (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4576959-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0153083-A2 | 6-Substituted-4-dialkylaminotetrahydrobenz(c,d)indoles | ELI LILLY AND COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |