Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697652 | 0.81 | KDM4E (0.39) | KDM4ELMNAEPHX2ALDH1A1GAA | |
| SCHEMBL32688556 | 0.78 | KDM4E (0.37) | KDM4ELMNAEPHX2ALDH1A1 | |
| SCHEMBL32689192 | 0.77 | KDM4E (0.36) | KDM4ELMNAEPHX2ALDH1A1 | |
| SCHEMBL4608572 | 0.74 | KDM4E (0.38) | KDM4ELMNAEPHX2ALDH1A1GAA | |
| SCHEMBL32689197 | 0.74 | KDM4E (0.34) | KDM4ELMNAEPHX2ALDH1A1 | |
| SCHEMBL14053439 | 0.73 | GRM5 (0.47) | KDM4ELMNAMEN1KMT2A | |
| SCHEMBL22009108 | 0.73 | KDM4E (0.40) | KDM4ELMNAEPHX2MEN1KMT2A | |
| SCHEMBL22009109 | 0.73 | KDM4E (0.40) | KDM4ELMNAEPHX2MEN1KMT2A | |
| SCHEMBL22009110 | 0.73 | KDM4E (0.40) | KDM4ELMNAEPHX2MEN1KMT2A | |
| SCHEMBL22009120 | 0.73 | KDM4E (0.40) | KDM4ELMNAEPHX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0097453-B1 | ALICYCLIC SUBSTITUTED OXAZOLIDINE-2,4-DIONES HAVING HYPOGLYCEMIC ACTIVITY | PFIZER INC. (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4430337-A | Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity | PFIZER INC. (US) | 1984-02-07 | — | — | US | disclosed |
| EP-0097453-A2 | Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity | PFIZER INC. (US) | 1984-01-04 | — | — | EP | disclosed |