Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10347495 | 1.00 | EGFR (0.40) | EGFRALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL14995184 | 0.98 | EGFR (0.39) | EGFRALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL14995186 | 0.98 | EGFR (0.39) | EGFRALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL4514887 | 0.76 | EGFR (0.47) | EGFRALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL1567233 | 0.75 | EGFR (0.37) | EGFRALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL1567232 | 0.75 | EGFR (0.37) | EGFRALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL16267237 | 0.74 | CES2 (0.31) | — | |
| SCHEMBL16267236 | 0.74 | CES2 (0.31) | — | |
| SCHEMBL16267235 | 0.74 | CES2 (0.31) | — | |
| SCHEMBL12658803 | 0.74 | EGFR (0.46) | EGFRALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0097453-B1 | ALICYCLIC SUBSTITUTED OXAZOLIDINE-2,4-DIONES HAVING HYPOGLYCEMIC ACTIVITY | PFIZER INC. (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4430337-A | Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity | PFIZER INC. (US) | 1984-02-07 | — | — | US | disclosed |
| EP-0097453-A2 | Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity | PFIZER INC. (US) | 1984-01-04 | — | — | EP | disclosed |