CES2

Cocaine esterase · O00748 · CES2 on Sugi Atlas →

272,868 patent compounds predicted against CES2, 159,995 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Benzil (SCHEMBL66)	1.00	12/20
Benzoyl Formic Acid (SCHEMBL38943)	0.77	11/20
SCHEMBL36097	0.41	6/20
Benzoin (SCHEMBL145)	1.00	5/20
Enoxolone (SCHEMBL18539)	1.00	5/20
Enoxolone (SCHEMBL18540)	1.00	5/20
Enoxolone (SCHEMBL25465)	1.00	5/20
SCHEMBL29518	0.65	5/20
SCHEMBL22540	0.58	5/20
SCHEMBL39274	0.55	5/20
Hydrochloric Acid (SCHEMBL28875)	0.53	5/20
SCHEMBL21310	0.48	5/20
Benzoin (SCHEMBL37126)	0.78	4/20
Benzoin (SCHEMBL25826)	0.75	4/20
SCHEMBL5725	0.68	4/20
SCHEMBL29091	0.68	4/20
SCHEMBL36634	0.68	4/20
Stearic Acid (SCHEMBL935)	0.67	4/20
Stearic Acid (SCHEMBL2371)	0.67	4/20
Stearic Acid (SCHEMBL4099)	0.67	4/20

Clinical trials — most relevant to CES2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD	PHASE4	RECRUITING
Impact of CES1 Genotype on Metabolism of Methylphenidate	PHASE4	COMPLETED
Characterisation of the Human Carboxylesterase 1 (CES1) Mutations in Thailand	PHASE4	COMPLETED
Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior	PHASE2	COMPLETED
Disulfiram for Cocaine Abuse in Buprenorphine Treatment	PHASE2	COMPLETED
Pharmacological Modulation of Cocaine Effects - 1	PHASE2	COMPLETED
Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics	PHASE2	WITHDRAWN
Pharmacogenetics of Disulfiram for Cocaine	PHASE2	COMPLETED
Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9	PHASE2	COMPLETED
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving	PHASE2	COMPLETED
Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7	PHASE2	COMPLETED
Effects of Aripiprazole on Cocaine Craving and Self-Administration	PHASE2	COMPLETED
Psychopharmacology for Cocaine Dependence - Buspirone	PHASE2	COMPLETED
Alcohol Inhibits Drug Metabolism by Carboxylesterases	PHASE1	COMPLETED
Interactions Between Intravenous Cocaine and Acetazolamide or Quinine	PHASE1	COMPLETED
Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine	PHASE1	WITHDRAWN
PK Study of Intranasal RX0041-002 in Subjects With Severe Renal Impairment and Normal Renal Function	PHASE1	COMPLETED
Agonist Replacement Therapy for Cocaine Dependence	PHASE1	COMPLETED
Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE)	PHASE1	COMPLETED
Vigabatrin Ph 1 Cocaine Interaction Study	PHASE1	COMPLETED
AAV8-hCocH for Cocaine Use Disorder	PHASE1	ACTIVE_NOT_RECRUITING
A Study of the Pharmacology of Oseltamivir (Tamiflu) in Pregnancy	PHASE1	WITHDRAWN
Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study	PHASE1	COMPLETED
Pharmacokinetic Study of Intranasal RX0041-002 in Hepatic-Impaired Individuals and Subjects With Normal Hepatic Function	PHASE1	COMPLETED
[11C]NOP-1A and Cocaine Use Disorders	EARLY_PHASE1	COMPLETED
Imaging CRF X NOP Interactions in CUD	EARLY_PHASE1	RECRUITING
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED
The Relationship Between CES1 Genotype and Methylphenidate Response in Children With ADHD - INDICES Work Package 6	nan	COMPLETED
Clinical and Atherosclerotic Characteristics of Patients With ACS Associated With Cocaine Use	nan	UNKNOWN
Brain Imaging of Cocaine Craving in Recreational Cocaine Users	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CES2 binder may also engage these)

Protein	Name	Similarity
Q91WG0	—	1.000	Q91WG0 →
Q8K3R0	—	1.000	Q8K3R0 →
Q63880	—	1.000	Q63880 →
Q5RCL7	—	1.000	Q5RCL7 →
Q8BK48	—	0.998	Q8BK48 →
Q8QZR3	—	0.998	Q8QZR3 →
Q64419	—	0.998	Q64419 →
Q8R0W5	—	0.997	Q8R0W5 →
Q8VCC2	—	0.997	Q8VCC2 →
Q6UWW8	—	0.996	Q6UWW8 →
P10959	—	0.996	P10959 →
Q63108	—	0.996	Q63108 →
Q6NT32	—	0.996	Q6NT32 →
P23953	—	0.995	P23953 →
P14943	—	0.995	P14943 →
O70631	—	0.995	O70631 →
CES1	Liver carboxylesterase 1	0.995	landscape →
Q6AW47	—	0.994	Q6AW47 →
O46421	—	0.994	O46421 →
P0C6R3	—	0.994	P0C6R3 →
G3V7J5	—	0.994	G3V7J5 →
Q8VCU1	—	0.994	Q8VCU1 →
Q92035	—	0.994	Q92035 →
Q64176	—	0.993	Q64176 →
Q5GRG2	—	0.993	Q5GRG2 →
Q29550	—	0.993	Q29550 →
Q63010	—	0.992	Q63010 →
Q5XG92	—	0.992	Q5XG92 →
P21836	—	0.991	P21836 →
P37136	—	0.990	P37136 →