Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10348282 | 1.00 | BACE1 (0.59) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL11813391 | 0.87 | BACE1 (0.62) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL14875223 | 0.85 | HDAC8 (0.70) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL14875220 | 0.85 | HDAC8 (0.70) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL2690696 | 0.83 | HDAC8 (0.55) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL2690695 | 0.83 | HDAC8 (0.55) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL10986381 | 0.83 | NFE2L2 (0.53) | BACE1ALDH1A1HPGDNFE2L2SMN1; SMN2 | |
| SCHEMBL10662067 | 0.83 | BACE1 (0.55) | BACE1HDAC8HDAC6PLK1MTNR1A | |
| SCHEMBL11791165 | 0.82 | NFE2L2 (0.49) | BACE1ALDH1A1HPGDNFE2L2SMN1; SMN2 | |
| SCHEMBL10348525 | 0.82 | MAPT (0.53) | BACE1ALDH1A1NFE2L2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | claimed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | claimed |
| US-4649157-A | ANTIALLERGENS, ANTIINFLAMMATORY | G. D. SEARLE & CO. (US) | 1987-03-10 | — | — | US | claimed |
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4761503-A | LEUKOTRIENE BIOSYNTHESIS INHIBITORS CONDENSATION OF BENZALDEHYDE WITH ACETOACETATE COMPOUND | G. D. SEARLE & CO. (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | disclosed |
| US-4649157-A | ANTIALLERGENS, ANTIINFLAMMATORY | G. D. SEARLE & CO. (US) | 1987-03-10 | — | — | US | disclosed |
| US-4136187-A | CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-01-23 | — | — | US | disclosed |
| US-3959292-A | HYPOTENSIVE AGENTS, CORONARY DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |