SCHEMBL10348692

SCHEMBL10348692

c1ccc2c(c1)CCc1cc3c(cc1-2)CCCC3

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
SRD5A1 P18405 1/20 0.47
SRD5A2 P31213 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
HPGD P15428 1/20 0.47
CYP2A6 P11509 1/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
CES1 P23141 1/20 0.46
DRD1 P21728 1/20 0.44
DRD5 P21918 1/20 0.44
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
NOS3 P29474 1/20 0.41
MITF O75030 1/20 0.40
HSP90AA1 P07900 1/20 0.40
CDC25B P30305 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
SETD7 Q8WTS6 1/20 0.37
DRD4 P21917 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4818156 0.89 CES1 (0.56) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL28852865 0.85 ALDH1A1 (0.52) TSHRSRD5A2L3MBTL1HPGDCYP2A6
SCHEMBL568779 0.83 TSHR (0.71) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL31430380 0.83 TSHR (0.71) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL31135519 0.81 TSHR (0.67) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL30731351 0.81 TSHR (0.67) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL31621255 0.81 TSHR (0.67) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL30668198 0.81 TSHR (0.67) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL30436120 0.81 TSHR (0.67) TSHRSRD5A1SRD5A2L3MBTL1HPGD
SCHEMBL29593589 0.81 TSHR (0.67) TSHRSRD5A1SRD5A2L3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0182609-B1 POLYCYCLIC BIOCIDAL COMPOUNDS, THEIR SYNTHESIS, FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1990-05-09 EP disclosed
US-4882358-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-11-21 US disclosed
US-4827034-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1989-05-02 US disclosed
US-4818443-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-04-04 US disclosed
US-4814502-A ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS BURROUGHS WELLCOME CO. (US) 1989-03-21 US disclosed
US-4810823-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-03-07 US disclosed
US-4808753-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-28 US disclosed
US-4791233-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-12-13 US disclosed
US-4791231-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-12-13 US disclosed
US-4791232-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-12-13 US disclosed
EP-0182609-A2 Polycyclic biocidal compounds, their synthesis, formulations containing them THE WELLCOME FOUNDATION LIMITED (GB) 1986-05-28 EP disclosed