Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 20/20 | 0.56 |
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | CA4 | P22748 | 5/20 | 0.56 |
| ▸ | CA5A | P35218 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.56 |
| ▸ | CA6 | P23280 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CA3 | P07451 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10348099 | 0.85 | CA2 (0.60) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10348738 | 0.83 | CA2 (0.58) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10348094 | 0.81 | CA2 (0.58) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10348595 | 0.77 | CA2 (0.56) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10985759 | 0.76 | CA2 (0.58) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10348598 | 0.75 | CA2 (0.57) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL2616102 | 0.73 | CA2 (0.69) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10347747 | 0.73 | CA2 (0.58) | CA2CA1CA4CA5ACA12 | |
| SCHEMBL10980308 | 0.72 | CA2 (0.59) | CA2CA1CA4CA5ACA12 | |
| Ethoxzolamide SCHEMBL63941 | 0.72 | CA2 (1.00) | CA2CA1CA4CA5ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122831-B1 | BENZOTHIAZOLE-2-SULFONAMIDE DERIVATIVES FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4499103-A | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0122831-A2 | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1984-10-24 | — | — | EP | disclosed |