Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.55 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598795 | 0.92 | TDP1 (0.61) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL5598797 | 0.92 | TDP1 (0.61) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL19520280 | 0.87 | TDP1 (0.60) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL19520282 | 0.87 | TDP1 (0.60) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL5231718 | 0.84 | TDP1 (0.61) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL2622483 | 0.84 | TDP1 (0.61) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL27727863 | 0.82 | TDP1 (0.59) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL11176315 | 0.82 | PTPN1 (0.50) | MAPTCYP1A2CYP1B1NPC1 | |
| SCHEMBL4267566 | 0.81 | TDP1 (0.58) | TDP1GLAHDAC3HDAC4HDAC1 | |
| SCHEMBL3308815 | 0.81 | TDP1 (0.57) | TDP1GLAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | disclosed |