Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10031558 | 0.82 | MCL1 (0.67) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL18195409 | 0.78 | MCL1 (0.61) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL16599480 | 0.78 | MCL1 (0.76) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL3587743 | 0.77 | MCL1 (0.59) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL15979629 | 0.77 | MCL1 (0.64) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL117186 | 0.76 | MCL1 (1.00) | MCL1SLC9A1MAPTPHGDHMEN1 | |
| SCHEMBL401039 | 0.76 | MCL1 (0.73) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL10350031 | 0.75 | MCL1 (0.61) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL2323444 | 0.75 | MCL1 (0.71) | MCL1SLC9A1IDO1MAPTPHGDH | |
| SCHEMBL2322980 | 0.75 | MCL1 (0.71) | MCL1SLC9A1IDO1MAPTPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201221-B1 | 6-(1-ACYL-1-HYDROXY METHYL) PENICILLANIC ACID DERIVATIVES | PFIZER INC. (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4762921-A | 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives | PFIZER INC. (US) | 1988-08-09 | — | — | US | disclosed |
| US-4675186-A | 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives | PFIZER INC. (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0201221-A1 | 6-(1-acyl-1-hydroxy methyl) penicillanic acid derivatives | PFIZER INC. (US) | 1986-11-12 | — | — | EP | disclosed |