SCHEMBL10353050

SCHEMBL10353050

COC(=O)C(=Cc1ccc(Br)cc1)C(C)=O

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.57
LMNA P02545 2/20 0.57
KMT2A Q03164 2/20 0.57
MEN1 O00255 1/20 0.57
S1PR4 O95977 1/20 0.57
S1PR1 P21453 1/20 0.57
MAPK1 P28482 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
HPGD P15428 1/20 0.53
KDM4E B2RXH2 4/20 0.50
ALDH1A1 P00352 2/20 0.50
TDP1 Q9NUW8 2/20 0.47
GLA P06280 1/20 0.47
POLB P06746 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
GAA P10253 1/20 0.46
HSP90AA1 P07900 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2812581 0.91 MAPT (0.67) MAPTLMNAKMT2AMEN1S1PR4
SCHEMBL12630700 0.85 ALDH1A1 (0.67) MAPTLMNAKMT2AMEN1S1PR4
SCHEMBL10353052 0.84 KDM4E (0.52) MAPTKMT2AMEN1HPGDKDM4E
SCHEMBL9401645 0.84 KDM4E (0.52) MAPTKMT2AMEN1HPGDKDM4E
SCHEMBL6508831 0.84 ALDH1A1 (0.72) MAPTKDM4EALDH1A1TDP1GLA
SCHEMBL9401639 0.84 KDM4E (0.52) MAPTKMT2AMEN1HPGDKDM4E
SCHEMBL6508829 0.84 ALDH1A1 (0.72) MAPTKDM4EALDH1A1TDP1GLA
SCHEMBL4217444 0.84 MAPT (0.53) MAPTLMNAKMT2AMEN1S1PR4
SCHEMBL13939604 0.83 MAPT (0.57) MAPTLMNAKMT2AMEN1NPSR1
SCHEMBL8036277 0.83 ALDH1A1 (0.50) MAPTKDM4EALDH1A1TDP1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0381699-A1 ALKYLENE AND DIALKYL KETALS AND ALKYL ALPHA-ENOL ETHERS OF ALPHA-ACETYL CINNAMIC ACIDS AND ESTERS THEREOF EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-08-16 EP disclosed
EP-0380585-A1 PROCESS FOR PREPARING 2-NAPHTHANOIC ACIDS AND ESTERS THEREOF EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-08-08 EP disclosed
WO-1989003377-A1 PROCESS FOR PREPARING 2-NAPHTHANOIC ACIDS AND ESTERS THEREOF EASTMAN KODAK COMPANY (US) 1989-04-20 WO disclosed
WO-1989003381-A1 ALKYLENE AND DIALKYL KETALS AND ALKYL ALPHA-ENOL ETHERS OF ALPHA-ACETYL CINNAMIC ACIDS AND ESTERS THEREOF EASTMAN KODAK COMPANY (US) 1989-04-20 WO disclosed
US-4761496-A Alkylene and diakyl ketals and alkyl alpha-enol ethers of alpha-acetyl cinnamic acids and esters thereof EASTMAN KODAK COMPANY (US) 1988-08-02 US disclosed
US-4761497-A Process for preparing 2-naphthanoic acids and esters thereof EASTMAN KODAK COMPANY (US) 1988-08-02 US disclosed