SCHEMBL10353152

SCHEMBL10353152

COC(=O)C(=Cc1cccc(OC)c1)C(C)=O

nearest known ligand 0.88

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.54
ALDH1A1 P00352 1/20 0.54
KMT2A Q03164 1/20 0.54
CHRM5 P08912 1/20 0.50
GAA P10253 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
MAPT P10636 4/20 0.48
KDM4E B2RXH2 1/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
HPGD P15428 1/20 0.48
FOS P01100 1/20 0.47
JUN P05412 1/20 0.47
BCHE P06276 1/20 0.47
MAOB P27338 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10755317 1.00 MEN1 (0.54) MEN1ALDH1A1KMT2ACHRM5GAA
SCHEMBL14462727 0.94 MEN1 (0.59) MEN1ALDH1A1KMT2ACHRM5MAPT
SCHEMBL9475106 0.86 MEN1 (0.62) MEN1ALDH1A1KMT2ACHRM5GAA
SCHEMBL7421645 0.86 MEN1 (0.62) MEN1ALDH1A1KMT2ACHRM5GAA
SCHEMBL10376285 0.86 GLO1 (0.64) MEN1ALDH1A1KMT2AGAATDP1
SCHEMBL7271180 0.86 GLO1 (0.64) MEN1ALDH1A1KMT2AGAATDP1
SCHEMBL8801981 0.84 MEN1 (0.56) MEN1ALDH1A1KMT2ACHRM5MAPT
SCHEMBL6954032 0.84 MAPT (0.49) ALDH1A1GAATDP1MAPTKDM4E
SCHEMBL6954037 0.84 MAPT (0.49) ALDH1A1GAATDP1MAPTKDM4E
SCHEMBL31634795 0.84 MAPT (0.49) ALDH1A1GAATDP1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0380585-A1 PROCESS FOR PREPARING 2-NAPHTHANOIC ACIDS AND ESTERS THEREOF EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-08-08 EP disclosed
WO-1989003377-A1 PROCESS FOR PREPARING 2-NAPHTHANOIC ACIDS AND ESTERS THEREOF EASTMAN KODAK COMPANY (US) 1989-04-20 WO disclosed
US-4761497-A Process for preparing 2-naphthanoic acids and esters thereof EASTMAN KODAK COMPANY (US) 1988-08-02 US disclosed
US-4727066-A CARDIOVASCULAR DISORDERS CERMOL S.A. (CH) 1988-02-23 US disclosed
US-4707479-A CARDIOVASCULAR DISORDERS, BLOOD SUGAR CONTROL BAYER AKTIENGESELLSCHAFT (DE) 1987-11-17 US disclosed
US-4656181-A CARDIOTONIC AGENTS CERMOL S.A. (CH) 1987-04-07 US disclosed