GLO1

Lactoylglutathione lyase · Q04760 · GLO1 on Sugi Atlas →

39,958 patent compounds predicted against GLO1, 27,528 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Delphinidin (SCHEMBL22369)	1.00	6/20
Delphinidin (SCHEMBL22370)	1.00	6/20
SCHEMBL345986	0.73	6/20
Quercetin (SCHEMBL19723)	1.00	5/20
Pelargonidin (SCHEMBL20591)	1.00	5/20
Pelargonidin (SCHEMBL20592)	1.00	5/20
Quercetin (SCHEMBL118425)	1.00	5/20
Cyanidin (SCHEMBL156277)	1.00	5/20
Cyanidin (SCHEMBL20799)	0.97	5/20
Delphinidin (SCHEMBL157864)	0.97	5/20
Pelargonidin (SCHEMBL157915)	0.97	5/20
Quercetin (SCHEMBL288466)	0.92	5/20
Petunidin (SCHEMBL21649)	0.76	5/20
Petunidin (SCHEMBL21650)	0.75	5/20
SCHEMBL79945	0.71	5/20
Peonidin (SCHEMBL20016)	0.70	5/20
Malvidin (SCHEMBL308690)	0.68	5/20
Malvidin (SCHEMBL21739)	0.68	5/20
Peonidin (SCHEMBL20017)	0.68	5/20
SCHEMBL105469	0.64	5/20

Clinical trials — most relevant to GLO1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Paracetamol Study in Patients With Low Muscle Mass	PHASE4	UNKNOWN
Cysteine Supplementation in Critically Ill Neonates	PHASE2/PHASE3	UNKNOWN
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype	PHASE2	ACTIVE_NOT_RECRUITING
Serine Supplementation for Obese Subjects With Fatty Liver Disease	PHASE1/PHASE2	COMPLETED
Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia	PHASE2	WITHDRAWN
Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals	PHASE1/PHASE2	WITHDRAWN
Tolerability of Enteral NAC in Infants	PHASE1	NOT_YET_RECRUITING
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels	PHASE1	COMPLETED
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM	PHASE1	WITHDRAWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Acute Glycine Pharmacodynamic Study	nan	COMPLETED
Primary Hyperoxaluria Mutation Genotyping/Phenotyping	nan	COMPLETED
Review of French Cases of Glutathione Synthetase Deficiency	nan	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
The Effect of Pyridoxamine Supplementation on Microvascular Function in Type 2 Diabetes	nan	COMPLETED
Treatment of Metastatic Cancer in Terminally Diagnosed Patients	nan	AVAILABLE
Broccoli and Vascular Health Study	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Molecular Epidemiology of Childhood Leukemia (Aka The California Childhood Leukemia Study)	nan	COMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS	nan	RECRUITING
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Investigation of Oxidative Markers and Antioxidant Defense in Female Patients With Osteoarthritis	nan	UNKNOWN
The Conversion of ENcapsulated GlucorAphanin, Gut Microbiota Phylogeny and gEnotype Study (ENGAGE)	nan	COMPLETED
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Impact of Glycemic Control on Penile Duplex Results	nan	NOT_YET_RECRUITING
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease	nan	COMPLETED
Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans	nan	COMPLETED
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GLO1 binder may also engage these)

Protein	Name	Similarity
Q4R5F2	—	1.000	Q4R5F2 →
Q6P7Q4	—	1.000	Q6P7Q4 →
Q9CPU0	—	0.998	Q9CPU0 →
Q42891	—	0.994	Q42891 →
O49818	—	0.992	O49818 →
O04885	—	0.992	O04885 →
Q9ZS21	—	0.992	Q9ZS21 →
Q8H0V3	—	0.987	Q8H0V3 →
Q502D1	—	0.966	Q502D1 →
Q4KLB0	—	0.963	Q4KLB0 →
Q9D8I3	—	0.962	Q9D8I3 →
A6NK44	—	0.960	A6NK44 →
P16635	—	0.958	P16635 →
P0C5H0	—	0.957	P0C5H0 →
Q28CR0	—	0.955	Q28CR0 →
P0AC81	—	0.952	P0AC81 →
Q9CPV4	—	0.951	Q9CPV4 →
P0A1Q2	—	0.950	P0A1Q2 →
PRMT5	Protein arginine N-methyltransferase 5	0.950	landscape →
A4FUZ6	—	0.950	A4FUZ6 →
Q6DI37	—	0.950	Q6DI37 →
P80064	—	0.950	P80064 →
Q9EQR2	—	0.950	Q9EQR2 →
Q66KC4	—	0.949	Q66KC4 →
Q8AVL0	—	0.949	Q8AVL0 →
Q99JT9	—	0.949	Q99JT9 →
O06695	—	0.949	O06695 →
Q5I0D1	—	0.949	Q5I0D1 →
P44638	—	0.949	P44638 →
P0A1Q3	—	0.948	P0A1Q3 →