Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328985 | 0.86 | MAPT (1.00) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL10507614 | 0.83 | MAPT (0.56) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7164868 | 0.80 | MAPT (0.84) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL95561 | 0.79 | MAPT (1.00) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL10353546 | 0.79 | MAPT (0.72) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL10353602 | 0.79 | MAPT (0.72) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7170786 | 0.79 | MAPT (0.68) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL10353552 | 0.78 | MAPT (0.76) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL102602 | 0.78 | MAPT (0.77) | MAPTL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL9781715 | 0.77 | KAT2B (0.64) | MAPTL3MBTL1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190817-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-05 | — | — | EP | disclosed |
| US-4857540-A | 1-SUBSTITUTED-2-MERCAPTO-(OR AMINOMETHYL-)BENZAMIDAZOLE COMPOUNDS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |
| US-4728741-A | DOPAMINE BETA-HYDROXYLASE INHIBITOR | SMITHKLINE BECKMAN CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0190817-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1986-08-13 | — | — | EP | disclosed |