Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.71 |
| ▸ | PDE4A | P27815 | 3/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.68 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.62 |
| ▸ | GALR3 | O60755 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687674 | 0.93 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL22317993 | 0.93 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10016799 | 0.93 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11633346 | 0.93 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8342501 | 0.93 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157007 | 0.92 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157017 | 0.92 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6856944 | 0.92 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11397791 | 0.92 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7338020 | 0.92 | PDE3B (0.66) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208517-B1 | 6-OXO-PYRIDAZINYL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-12 | — | — | EP | claimed |
| US-4904664-A | INOTROPIC, BRONCHODILATOR, AND VASODILATOR AGENTS; CONGESTIVE HEART FAILURE; CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-27 | — | — | US | claimed |
| EP-0208517-A2 | 6-Oxo-pyridazinyl compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-01-14 | — | — | EP | claimed |
| EP-0208517-B1 | 6-OXO-PYRIDAZINYL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-12 | — | — | EP | disclosed |
| US-4904664-A | INOTROPIC, BRONCHODILATOR, AND VASODILATOR AGENTS; CONGESTIVE HEART FAILURE; CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| EP-0208517-A2 | 6-Oxo-pyridazinyl compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-01-14 | — | — | EP | disclosed |