Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.64 |
| ▸ | PDE4A | P27815 | 3/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.61 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353457 | 0.93 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL22317993 | 0.87 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10016799 | 0.87 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11633346 | 0.87 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8342501 | 0.87 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11397791 | 0.85 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157007 | 0.85 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6856944 | 0.85 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157017 | 0.85 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11268997 | 0.85 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |