Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335066 | 0.85 | KDM4E (0.53) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL27281805 | 0.85 | KDM4E (0.48) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL28828282 | 0.83 | KDM4E (0.47) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL7863941 | 0.82 | MEN1 (0.44) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL951003 | 0.81 | KDM4E (0.48) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL10625931 | 0.81 | CYP3A4 (0.48) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL4314431 | 0.78 | KDM4E (0.50) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL28883530 | 0.78 | AKR1C2 (0.52) | KDM4ETDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL691741 | 0.78 | AKR1C2 (0.52) | KDM4ETDP1KMT2AMEN1TSHR | |
| SCHEMBL27754447 | 0.77 | CYP3A4 (0.44) | KDM4ETDP1KMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230532-B1 | 2-[(3,5-Dihalo-4-Aminobenzyl)] Imidazolines | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0230532-A1 | 2-[(3,5-Dihalo-4-Aminobenzyl)] Imidazolines | ABBOTT LABORATORIES (US) | 1987-08-05 | — | — | EP | disclosed |
| US-4665095-A | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion | ABBOTT LABORATORIES (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0107306-B1 | IMIDAZOLINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1986-04-30 | — | — | EP | disclosed |
| US-4505926-A | GASTROINTESTINAL DISORDERS ANTIDIARRHEA | BEECHAM GROUP P.L.C. (GB) | 1985-03-19 | — | — | US | disclosed |
| EP-0107306-A1 | Imidazoline derivatives | BEECHAM GROUP PLC (GB) | 1984-05-02 | — | — | EP | disclosed |