Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355091 | 0.92 | KDM4E (0.37) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9740880 | 0.83 | SRC (0.37) | — | |
| SCHEMBL10355483 | 0.76 | TSHR (0.39) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL10568973 | 0.76 | MAOB (0.37) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9739219 | 0.73 | KDM4E (0.40) | KDM4EMAPT | |
| SCHEMBL1091810 | 0.67 | NPSR1 (0.42) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4851597 | 0.66 | — | — | |
| SCHEMBL1965665 | 0.66 | GPR84 (0.37) | — | |
| SCHEMBL6011026 | 0.65 | GRIN2D (0.42) | KDM4EALDH1A1CYP3A4MAPTHPGD | |
| SCHEMBL25189382 | 0.64 | UHRF1 (0.33) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166183-B1 | USE OF HYDROXYINDOLE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING THE BLOOD PRESSURE | MERCK PATENT GmbH (DE) | 1990-10-03 | — | — | EP | disclosed |
| US-4711893-A | Use of hydroxyindole derivatives in lowering blood pressure | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0166183-A2 | Use of hydroxyindole derivatives for the manufacture of a medicament for lowering the blood pressure | MERCK PATENT GmbH (DE) | 1986-01-02 | — | — | EP | disclosed |